The Definitive Guide to ceesdekker
The Definitive Guide to ceesdekker
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‘Sure, that may be about proper. I try to find a physical comprehension of Organic systems in the base-up way. I think you might distinguish a few lines of investigation in my team in the mean time. The main issues chromosome framework: How does one get a metre-extended DNA polymer folded and organised in this type of microscopic mobile? We have created visualisation tactics that make it possible for us to check how, for instance, SMC proteins loop DNA (video clip on Youtube) so that you can build up chromosomes.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
, Groningen researchers present the outcome of their initiatives for making labs additional sustainable and supply guidelines for other labs.
2007, 1st serious-time detection of strand exchange in homologous recombination by RecA; discovery of a very low persistence length of ends of microtubules; and solved the mechanism of biosensing with carbon nanotubes
2015, discovery that condensin is a really versatile protein construction; and first detection of DNA knots applying nanopores
Within the many years following these discoveries, my investigate pursuits shifted to biophysics and nanobiology, And that i became significantly less involved in the event of nanotube electronics. The main focus of many researchers in the sphere also shifted to graphene (the place, funnily adequate, the initial graphene ribbons were called ‘nanotubes which are cut open up alongside their length’) after the invention of the two-dimensional materials in 2004.
Considering the fact that 2000 he moved to single-molecule biophysics and nanobiology, with investigate from DNA supercoiling experiments of nucleosomes and DNA repair service proteins to DNA translocation by way of nanopores. Not too long ago his study has centered on finding out cell division with micro organism on chip, even though his final interest is during the course of acknowledging synthetic cells.
Atomic drive microscopy exhibits that vaccinia topoisomerase IB generates filaments on ceesdekker.net DNA in a very cooperative style
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Right now, we also recognized that it should be achievable to utilize just one semiconducting carbon nanotube to create a transistor — and we set out to really make it. We stretched particular person semiconducting nanotubes throughout metallic electrodes and employed the underlying silicon substrate as a gate electrode, creating The essential 3-terminal layout of the industry-effect transistor (Fig.
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2001, discovery of solitary-electron transistors at place temperature based upon nanotubes; realization of to start with logic circuits with carbon nanotube devices; and discovery of the molecular structure of DNA repair enzymes with AFM
Developments in nanotechnology during the nineteen nineties made building electronic devices from one molecules a possibility. Cees Dekker recounts how his team created a room-temperature transistor according to a single carbon nanotube.
2013, controlled shaping of Stay bacterial cells into arbitrary shapes; and discovery of spontaneous fluctuations during the handedness of histone tetrasomes